Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …

G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one
of the most studied transmembrane cell signaling pathways. However, it is unknown whether …

The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …

The striatal dopamine D 2 receptor (D 2 R) is generally accepted to be involved in positive
symptoms of schizophrenia and is a main target for clinically used antipsychotics. D 2 R are …

According to the adenosine hypothesis of schizophrenia, the classically associated
hyperdopaminergic state may be secondary to a loss of function of the adenosinergic …

Recent studies on interactions between striatal adenosine and dopamine and one of its
main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer …

Background: Several biophysical techniques have been successfully implemented to detect
G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

G protein-coupled adenosine receptors are promising therapeutic targets for a wide range of
neuropathological conditions, including Parkinson's disease (PD). However, the ubiquity of …