[HTML][HTML] The sirtuin family in health and disease
QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
[HTML][HTML] The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
[HTML][HTML] NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
[HTML][HTML] Macrophage polarization and reprogramming in acute inflammation: a redox perspective
S Pérez, S Rius-Pérez - Antioxidants, 2022 - mdpi.com
Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …
[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …
every living cell, is involved in a myriad of metabolic processes associated with cellular …
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and …
Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …
NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction
D Tong, GG Schiattarella, N Jiang… - Circulation …, 2021 - Am Heart Assoc
Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical
syndrome without effective therapies. We recently demonstrated in mice that a combination …
syndrome without effective therapies. We recently demonstrated in mice that a combination …