Specific expression and functions of circular RNAs

S Misir, N Wu, BB Yang - Cell Death & Differentiation, 2022 - nature.com
In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by
their covalently closed circular structure, have become a new research paradigm in RNA …

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

M Su, Y Xiao, J Ma, Y Tang, B Tian, Y Zhang, X Li… - Molecular cancer, 2019 - Springer
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability.
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …

CircRNAs and cancer: biomarkers and master regulators

E Arnaiz, C Sole, L Manterola, L Iparraguirre… - Seminars in cancer …, 2019 - Elsevier
Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively
abundant have only recently begun to be explored. There are many thousands of genes that …

Circular RNAs: biogenesis, function and role in human diseases

J Greene, AM Baird, L Brady, M Lim… - Frontiers in molecular …, 2017 - frontiersin.org
Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike
linear RNAs, form covalently closed continuous loops and act as gene regulators in …

A comprehensive overview and evaluation of circular RNA detection tools

X Zeng, W Lin, M Guo, Q Zou - PLoS computational biology, 2017 - journals.plos.org
Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon
joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been …

Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein

X Cheng, L Zhang, K Zhang, G Zhang, Y Hu… - Annals of the …, 2018 - ard.bmj.com
Objectives Circular RNAs (circRNAs) have been proven to function as competing
endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of …

Overexpression of circular RNA ciRS‐7 abrogates the tumor suppressive effect of miR‐7 on gastric cancer via PTEN/PI3K/AKT signaling pathway

H Pan, T Li, Y Jiang, C Pan, Y Ding… - Journal of cellular …, 2018 - Wiley Online Library
Gastric cancer (GC) has one of the highest mortality rates of malignancies globally.
Currently, ciRS‐7, a novel circular RNA, has emerged as a potential sponge for miR‐7 …

Circular RNAs (circRNAs) in health and disease

S Haque, LW Harries - Genes, 2017 - mdpi.com
Splicing events do not always produce a linear transcript. Circular RNAs (circRNAs) are a
class of RNA that are emerging as key new members of the gene regulatory milieu, which …

[HTML][HTML] Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer

H Zhang, Z Ge, Z Wang, Y Gao, Y Wang, X Qu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
To explore the effect of circRHOT1 on breast cancer progression and the underlying
mechanism. Significantly, our data revealed that the depletion of circRHOT1 was able to …

CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13

R Li, S Ke, F Meng, J Lu, X Zou, Z He, W Wang… - Cell death & …, 2018 - nature.com
The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various
tumors, including gastric and colorectal cancer. However, the role of ciRS-7 in esophageal …