Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

The citric acid cycle is the final common oxidative pathway for carbohydrates, fats and amino
acids. It is the most important metabolic pathway for the energy supply to the body. TCA is …

Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

Adaptation to different nutritional environments is essential for life cycle completion by all
Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most …

Mechanisms of regulation of mitochondrial metabolism in trypanosomes are not completely
understood. Here we present evidence that the Trypanosoma brucei mitochondrial calcium …

The metabolism of Trypanosomatidae differs significantly between distinct species and can
even be completely different between various life-cycle stages of the same species. It has …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

It is becoming increasingly clear that under natural conditions parasitic infections commonly
consist of co‐infections with multiple conspecific strains. Multiple‐strain infections lead to …

African trypanosomes go through at least five developmental stages during their life cycle.
The different cellular forms are classified using morphology, including the order of the …