Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …

It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

Peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent transcription
factor highly expressed in adipocytes, is a master regulator of adipogenesis and lipid …

To better understand the role of irisin in humans, we examined the effects of irisin in human
primary adipocytes and fresh human subcutaneous white adipose tissue (scWAT). Human …

In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Objective Increasing the amounts of functionally competent brown adipose tissue (BAT) in
adult humans has the potential to restore dysfunctional metabolism and counteract obesity …

Adipose tissue is traditionally categorized into white and brown relating to their function and
morphology. The classical white adipose tissue builds up energy in the form of triglycerides …

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear
factor IA (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin …