The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …

Fungal infections are a universal problem and are routinely associated with high morbidity
and mortality rates in immunocompromised patients. Existing therapies comprise five …

Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …

Modern cell membranes contain a bewildering complexity of lipids, among them
sphingolipids (SLs). Advances in mass spectrometry have led to the realization that the …

Introduction The antifungal therapy currently available includes three major classes of drugs:
polyenes, azoles and echinocandins. However, the clinical use of these compounds faces …

Fungal infections are becoming more prevalent and problematic due to the continual rise of
immune deficient patients as well as the progressive development of drug resistance …

Filamentous fungi are a group of economically important fungi used in the production of
fermented foods, industrial enzymes, and secondary metabolites. Glycosphingolipids (GSLs) …

Microbes have evolved multiple mechanisms to resist environmental stresses, which are
regulated in complex and delicate ways. Though the role of cell membranes in acid …

Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality
rates. Among the fungal determinants involved in the establishment of infection …

Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural
and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous …