Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

Effects of B cell depletion by rituximab, a monoclonal antibody to CD20, were studied in
patients with relapsing MS that had not responded optimally to standard immunomodulatory …

Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker
in MS, the most common demyelinating disease of the CNS. We have attempted to identify …

The diagnosis of multiple sclerosis is based on dissemination in time and space. Before
2010 lack of evidence for dissemination in space could be substituted by a paraclinical test …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

Background: The authors have recently described that intrathecal IgM synthesis (ITMS)
correlates with a higher disability in patients with clinically definite MS (CDMS). Objective: To …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an
autoimmune response against central nervous system (CNS) structures. Traditionally …