Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

Past, present, and future of naturally occurring antimicrobials related to snake venoms

N Oguiura, L Sanches, PV Duarte, MA Sulca-López… - Animals, 2023 - mdpi.com
Simple Summary A critical global health problem is microbial resistance to antibiotics. In
order to further discuss this issue and search for practical means to overcome such …

Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2

AE Siniavin, MA Streltsova, MA Nikiforova… - Cellular and Molecular …, 2021 - Springer
The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate
the symptoms and to prevent the spread of this disease. Previous studies demonstrated …

Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus

IA Santos, JF Shimizu, DM de Oliveira, DOS Martins… - Scientific Reports, 2021 - nature.com
Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally
spreading mosquito-borne disease. There is no approved antiviral or vaccine against …

Insights into the antiviral activity of phospholipases A2 (PLA2s) from snake venoms

SC Teixeira, BC Borges, VQ Oliveira… - International journal of …, 2020 - Elsevier
Viruses are associated with several human diseases that infect a large number of
individuals, hence directly affecting global health and economy. Owing to the lack of efficient …

[HTML][HTML] Roles of Bothrops jararacussu toxins I and II: Antiviral findings against Zika virus

NM Cassani, IA Santos, VR Grosche… - International Journal of …, 2023 - Elsevier
Zika virus is the etiologic agent of Zika fever, and has been previously associated with cases
of microcephaly, drawing the attention of the health authorities worldwide. However, no …

A meta-analysis of the protein components in rattlesnake venom

A Deshwal, P Phan, J Datta, R Kannan… - Toxins, 2021 - mdpi.com
The specificity and potency of venom components give them a unique advantage in
developing various pharmaceutical drugs. Though venom is a cocktail of proteins, rarely are …

Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors

GH Sampat, K Hiremath, J Dodakallanavar… - Pharmacological …, 2023 - Springer
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported
approximately 5 million people are bitten by various species of snakes each year, resulting …

Antiviral effects of animal toxins: is there a way to drugs?

Y Utkin, A Siniavin, I Kasheverov, V Tsetlin - International Journal of …, 2022 - mdpi.com
Viruses infect all types of organisms, causing viral diseases, which are very common in
humans. Since viruses use the metabolic pathways of their host cells to replicate, they are …

Immunotherapeutic potential of Crotoxin: Anti-inflammatory and immunosuppressive properties

MA Sartim, DL Menaldo, SV Sampaio - Journal of Venomous Animals …, 2019 - SciELO Brasil
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from
snake venoms, partially due to its major role as the main toxic component in the venom of …