Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Adoptive immunotherapy with regulatory T cells (Tregs) is a promising treatment for allograft
rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with …

Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently
being investigated clinically by us and others as a means of reducing allograft rejection …

Background Dysregulated inflammatory responses and oxidative stress are key pathogenic
drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells …

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …

CD4+ CD25 high FOXP3+ regulatory T cells (Tregs) are involved in graft-specific tolerance
after solid organ transplantation. However, adoptive transfer of polyspecific Tregs alone is …

Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …

Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and
limit other immune responses. They achieve this through different mechanisms including the …

Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …