Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Local regulation of T cell–mediated immunity to solid tumors occurs at multiple levels,
including their recruitment from the bloodstream to the tumor microenvironment (TME) …

Nuclear factors TOX and TOX2 upregulate TIM3 expression and lead to T-cell exhaustion in
malignancies. Here, we demonstrate two distinct TIM3 expression patterns (high & low) with …

Engineered cellular therapy with CD19-targeting chimeric antigen receptor T cells (CAR-Ts)
has revolutionized outcomes for patients with relapsed/refractory large B-cell lymphoma …

Single cell technologies have undergone significant transformation, expanding from their
initial focus on transcriptomics to encompass a diverse range of modalities. Recent …

Although chimeric antigen receptor (CAR) T cells are effective against B-lineage
malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These …

Background: The effect of the expression of the newly identified immune checkpoint, T cell
immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) on NK …

Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that is prevalent in
reproductive-age women worldwide. Adverse outcomes associated with BV include an …

In this issue of Blood, John et al apply spatial transcriptomics to gain insights into the spatial
complexity of extramedullary disease (EMD) in multiple myeloma (MM). 1 Location, location …

While immune checkpoint inhibitors have demonstrated durable responses in various
cancer types, a significant proportion of patients do not exhibit favourable responses to …