Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell
differentiation, and cell metabolism in many different cell types, both during embryogenesis …

Abstract The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA)
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …

Vitamin A is an essential nutrient required throughout life. Through its various metabolites,
vitamin A sustains fetal development, immunity, vision, and the maintenance, regulation, and …

All-trans retinoic acid is a morphogen during embryogenesis and a teratogen. Cancer is an
error of development, and the retinoic acid receptors (RAR) for all-trans retinoic acid play a …

Human cytochrome P450 (CYP) enzymes are widely known for their pivotal role in the
metabolism of drugs and other xenobiotics as well as of endogenous chemicals. In addition …

The systematic study of drug metabolism began in the 19th Century, but most of what we
know now has been learned in the last 50 years. Drug metabolism continues to play a …

Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …

The family of intracellular lipid binding proteins (iLBPs) is comprised of 16 members of
structurally related binding proteins that have ubiquitous tissue expression in humans. iLBPs …

This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid
(RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along …

The vitamin A metabolite, retinoic acid, is an important signaling molecule during embryonic
development serving critical roles in morphogenesis, organ patterning and skeletal and …