The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Dnmt2 enzymes have been widely conserved during evolution and contain all of the
signature motifs of DNA (cytosine-5)-methyltransferases; however, the DNA …

Comparisons of the DNA sequences of metazoa show an excess of transitional over
transversional substitutions. Part of this bias is due to the relatively high rate of mutation of …

Cancer is both a genetic and an epigenetic disease. Inactivation of tumour-suppressor
genes by epigenetic changes is frequently observed in human cancers, particularly as a …

Methylation of cytosine is one of the main epigenetic mechanisms involved in controlling
gene expression. Here we show that the pea aphid (Acyrthosiphon pisum) genome …

Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and
developmental regulation during its complex lifecycle and host interactions. DNA …

Highlights•The 3D genome organization in plants and animals is very similar.•Distant
regulatory elements and target genes interact through physical interactions.•Chromatin …

Transposable elements (TEs), by their capacity of moving and inducing mutations in the
genome, are considered important drivers of species evolution. The successful invasions of …

Transgenerational epigenetic inheritance, while poorly understood, is of great interest
because it might help explain the increase in the incidence of diseases with an …

Transgenerational epigenetic inheritance results from incomplete erasure of parental
epigenetic marks during epigenetic reprogramming at fertilization. The significance of this …