Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

Small-molecule-induced protein depletion technologies, also called inducible degrons,
allow degradation of genetically engineered target proteins within cells and animals. Here …

The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality
with the promise to tame disease-relevant proteins in ways that are difficult or impossible to …

Conditional control of protein expression facilitates studies of nuclear functions, which are
highly dynamic and tightly linked to the cell cycle in proliferating cells. However, conditional …

The field of epigenetics pertains to alterations in gene function that are inherited without
changes in the DNA sequence, including histone modifications, post-translational …

TGFβ (transforming growth factor-β) signaling is involved in a myriad of cellular processes
and its dysregulation has been implicated in many human diseases, including fibrosis and …

A general and practical method for the construction of various 3, 4, 5-trisubstituted 1, 2, 4-
triazoles via I2-catalyzed cycloaddition of N-functionalized amidines with hydrazones is …

In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality
also harbors unique properties that enable the development of innovative chemical biology …

Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD)
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …