[HTML][HTML] New insights into the roles of peroxiredoxins in cancer
Y Liu, P Wang, W Hu, D Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl) aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors
W Shuai, H Xiao, P Yang, Y Zhang, F Bu… - Journal of Medicinal …, 2024 - ACS Publications
The RAS-RAF-MEK-ERK signaling cascade is abnormally activated in various tumors,
playing a crucial role in mediating tumor progression. As the key component at the terminal …
playing a crucial role in mediating tumor progression. As the key component at the terminal …
Peroxiredoxin‐5 Knockdown Accelerates Pressure Overload‐Induced Cardiac Hypertrophy in Mice
C Hu, F Dai, J Wang, L Jiang, D Wang… - Oxidative Medicine …, 2022 - Wiley Online Library
A recent study showed that peroxiredoxins (Prxs) play an important role in the development
of pathological cardiac hypertrophy. However, the involvement of Prx5 in cardiac …
of pathological cardiac hypertrophy. However, the involvement of Prx5 in cardiac …
Wide-field endoscope accessory for multiplexed fluorescence imaging
A wide-field endoscope that is sensitive to fluorescence can be used as an adjunct to
conventional white light endoscopy by detecting multiple molecular targets concurrently. We …
conventional white light endoscopy by detecting multiple molecular targets concurrently. We …
GRAIL1 stabilizes misfolded mutant p53 through a ubiquitin ligase-independent, chaperone regulatory function
P Ray, S Jaiswal, D Ferrer-Torres, Z Wang… - Molecular Cancer …, 2024 - aacrjournals.org
Abstract Frequent (> 70%) TP53 mutations often promote its protein stabilization, driving
esophageal adenocarcinoma (EAC) development linked to poor survival and therapy …
esophageal adenocarcinoma (EAC) development linked to poor survival and therapy …
Phage Display Identified Novel Leydig Cell Homing Peptides for Testicular Targeting
Y Jirwankar, A Nair, S Marathe… - ACS Pharmacology & …, 2024 - ACS Publications
Conventional drug delivery methods to treat testicular disorders face various challenges,
which could be circumvented by using targeted drug delivery. Testicular cell targeting …
which could be circumvented by using targeted drug delivery. Testicular cell targeting …