[HTML][HTML] Potential roles of the gut microbiota in pancreatic carcinogenesis and therapeutics

Q Yang, J Zhang, Y Zhu - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The intestinal microenvironment is composed of normal gut microbiota and the environment
in which it lives. The largest microecosystem in the human body is the gut microbiota, which …

Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

RC Wheatley, E Kilgour, T Jacobs, A Lamarca… - British Journal of …, 2022 - nature.com
Biliary tract cancers, including intra-and extra-hepatic cholangiocarcinoma as well as
gallbladder cancer, are associated with poor prognosis and the majority of patients present …

[HTML][HTML] A comprehensive review of the current and future role of the microbiome in pancreatic ductal adenocarcinoma

N Merali, T Chouari, K Kayani, CJ Rayner, JI Jimenez… - Cancers, 2022 - mdpi.com
Simple Summary This review summarizes the current literature related to the microbiome
and pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to explore the …

[HTML][HTML] Pancreatic cancer and gut microbiome-related aspects: A comprehensive review and dietary recommendations

BK Sobocki, K Kaźmierczak-Siedlecka, M Folwarski… - Nutrients, 2021 - mdpi.com
Gut microbiota plays a significant role in the human body providing many beneficial effects
on the host. However, its dysbiotic alterations may affect the tumorigenic pathway and then …

[HTML][HTML] Bile Microbiome Signatures Associated with Pancreatic Ductal Adenocarcinoma Compared to Benign Disease: A UK Pilot Study

N Merali, T Chouari, J Terroire, MD Jessel… - International journal of …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) has a very poor survival. The intra-tumoural
microbiome can influence pancreatic tumourigenesis and chemoresistance and, therefore …

[HTML][HTML] Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

C Di Giorgio, R Bellini, A Lupia, C Massa… - Frontiers in …, 2023 - frontiersin.org
The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose
overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal …

[HTML][HTML] Microbiota in the natural history of pancreatic cancer: From predisposition to therapy

C Binda, G Gibiino, M Sbrancia, C Coluccio, M Cazzato… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic cancer is still burdened with a severe prognosis, despite
advances in the diagnosis and surgical management of this disease. The gut microbiome is …

[HTML][HTML] Drug repurposing opportunities in pancreatic ductal adenocarcinoma

R Rebelo, B Polónia, LL Santos, MH Vasconcelos… - Pharmaceuticals, 2021 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors
worldwide. The diagnosis is often possible only in the latter stages of the disease, with …

A high bile acid environment promotes apoptosis and inhibits migration in pancreatic cancer

S Zhu, K Yang, S Yang, L Zhang, M Xiong, J Zhang… - …, 2022 - Taylor & Francis
Bile acids, the main organic solutes in bile, have been established to play an important role
at physiological concentrations in gastrointestinal metabolism. However, under pathological …

[HTML][HTML] Harnessing the Microbiome to Reduce Pancreatic Cancer Burden

AR Bastos, J Pereira-Marques, RM Ferreira… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer has one of the worst prognoses among all the
malignancies. To date, there are no effective strategies for preventing, diagnosing, or …