The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All
potential pharmacological interventions have failed in clinical trials, meaning that symptom …

Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While …

Membrane protein structural biology is still a largely unconquered area, given that
approximately 25% of all proteins are membrane proteins and yet less than 150 unique …

Based on their unique combination of offering high water permeability and high solute
rejection aquaporin proteins have attracted considerable interest over the last years as …

Aquaporins are protein channels that facilitate the flow of water across plasma cell
membranes in response to osmotic gradients. This review summarizes the evidence that …

Antibodies to aquaporin‐4 (called NMO‐IgG or AQP4‐Ab) constitute a sensitive and highly
specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Background Aquaporins, also called major intrinsic proteins (MIPs), constitute an ancient
superfamily of channel proteins that facilitate the transport of water and small solutes across …