Breast cancer is the most common malignant tumor in females worldwide. Chemotherapy is
the standard breast cancer treatment; however, chemoresistance is often seen in patients …

Abstract Changes in lifestyle such as physical activity and eating habits have been one of
the main reasons for development of various diseases in modern world, especially cancer …

Motivation Single-cell RNA sequencing (scRNA-seq) data provides unprecedented
opportunities to reconstruct gene regulatory networks (GRNs) at fine-grained resolution …

Aspirin as a chemopreventive agent is able to restrict the tumor growth. Phosphoglycerate
mutase 1 (PGAM1) is a key enzyme of glycolysis, playing an important role in the …

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed
drug classes with wide therapeutic applications over the centuries. Starting from the use of …

Fibromodulin (FMOD) is an archetypal member of the class II small leucine-rich
proteoglycan family. By directly binding to extracellular matrix structural components, such …

Accumulating evidence has shown that fibromodulin (FMOD) plays a pivotal role in
tumorigenesis and metastasis. However, the biological function of FMOD in oral squamous …

Small leucine-rich proteoglycans (SLRPs) are major regulators of extracellular matrix
assembly and cell signaling. Lumican, a member of the SLRPs family, and its derived …

Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide.
Fibromodulin (FMOD) is the main proteoglycan that contributes to extracellular matrix (ECM) …

During aging, skin homeostasis is essential for maintaining appearance, as well as
biological defense of the human body. In this study, we identified thrombospondin-1 …