The coagulopathy, endotheliopathy, and vasculitis of COVID-19

T Iba, JM Connors, JH Levy - Inflammation Research, 2020 - Springer
Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the
elevated D-dimer without remarkable changes of other global coagulation markers is …

von Willebrand factor and platelet glycoprotein Ib: a thromboinflammatory axis in stroke

F Denorme, K Vanhoorelbeke… - Frontiers in …, 2019 - frontiersin.org
von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites
of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα …

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

SR Stowell, CP Stowell - Vox sanguinis, 2019 - Wiley Online Library
The ABH and Lewis antigens were among the first of the human red blood cell
polymorphisms to be identified and, in the case of the former, play a dominant role in …

[HTML][HTML] Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells

MM Lee‐Sundlov, SR Stowell… - Journal of Thrombosis and …, 2020 - Elsevier
Glycosylation is highly prevalent, and also one of the most complex and varied
posttranslational modifications. This large glycan diversity results in a wide range of …

Targeting von Willebrand factor in ischaemic stroke: focus on clinical evidence

N Buchtele, M Schwameis, JC Gilbert… - Thrombosis and …, 2018 - thieme-connect.com
Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke
remain unacceptably high. To address this issue, one potential target for novel therapeutics …

Implication of MicroRNA503 in brain endothelial cell function and ischemic stroke

H Zhang, Q Pan, Z Xie, Y Chen, J Wang, J Bihl… - Translational stroke …, 2020 - Springer
The role of miR-503 in brain endothelium and ischemic stroke (IS) remains unclear. We
aimed to study the relationship between plasma miR-503 and the onset time, severity …

The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients

KD Kovacevic, S Greisenegger, A Langer… - Scientific Reports, 2021 - nature.com
The effect of conventional anti-platelet agents is limited in secondary stroke prevention, and
their effects are blunted under high shear stress in the presence of increased levels of …

Applying machine learning to carotid sonographic features for recurrent stroke in patients with acute stroke

SY Lin, KM Law, YC Yeh, KC Wu, JH Lai… - Frontiers in …, 2022 - frontiersin.org
Background Although carotid sonographic features have been used as predictors of
recurrent stroke, few large-scale studies have explored the use of machine learning analysis …

Von Willebrand factor antigen levels predict poor outcomes in patients with stroke and cancer: findings from the multicenter, prospective, observational SCAN study

T Kawano, Y Gon, M Sakaguchi… - Journal of the …, 2024 - Am Heart Assoc
Background Patients with acute ischemic stroke and active cancer have more severe
neurological symptoms, elevated risks of stroke recurrence, and death compared with the …

[HTML][HTML] Von Willebrand factor antigen levels predict major adverse cardiovascular events in patients with carotid stenosis of the ICARAS study

KD Kovacevic, FJ Mayer, B Jilma, N Buchtele… - Atherosclerosis, 2019 - Elsevier
Abstract Background and aims Von Willebrand factor (VWF) plays an important role in
thrombogenesis and mediates platelet adhesion particularly under high shear stress. Such …