Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

Analysis of the interplay between cell proliferation and death has been greatly advantaged
by the development of CNS slice preparations. In slices, interactions between neurons and …

Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation,
and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders …

Increasing lines of evidence show that resveratrol, a polyphenol compound contained in
several dietary products, exhibits cytoprotective actions. Notably, resveratrol activates sirtuin …

Stem cell therapy is a promising treatment for neurological disorders such as cerebral
ischemia, Parkinson's disease and Huntington's disease. In recent years, many clinical trials …

Rotenone is a toxin used to generate animal models of Parkinson's disease; however, the
mechanisms of toxicity in substantia nigra pars compacta (SNc) neurons have not been well …

Previous studies suggested that amyloid β (Aβ)-induced disruption of astrocytic Ca 2+
signalling and oxidative stress play a major role in the progression towards neuronal and …

There is increasing evidence to suggest that neuroinflammatory processes contribute to the
cascade of events that lead to the progressive neuronal damage observed in …

The proximate cause of Parkinson's disease is striatal dopamine depletion. Although no
overt toxicity to striatal neurons has been reported in Parkinson's disease, one of the …

Glial cell line-derived neurotrophic factor (GDNF) is a potent trophic factor that supports the
survival of dopaminergic neurons of the substantia nigra (SN), which degenerate in …