Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Highlights•High-quality compound collections are a main determinant of drug discovery
success.•Generation of relevant collections is a significant challenge for any …

The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent
multicomponent reaction (MCRs) that has sparked organic chemists' interest in the field. It …

Miniaturization and acceleration of synthetic chemistry is an emerging area in
pharmaceutical, agrochemical, and materials research and development. Herein, we …

The compatibility of free boronic acid building blocks in multicomponent reactions to readily
create large libraries of diverse and complex small molecules was investigated …

Small conductance calcium-activated potassium (SK) channel activity has been proposed to
play a role in the pathology of several neurological diseases. Besides regulating plasma …

The area of covalent inhibitors is gaining momentum due to recently introduced clinical
drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) …

Based on a combination of an Ugi four component reaction and a ring closing metathesis, a
library of novel artificial macrocyclic inhibitors of the p53–MDM2 interaction was designed …

Alkyl isonitriles, R—NC, have previously been shown to ligate the heme (haem) iron of
cytochromes P450 in both accessible oxidation states (ferrous, Fe2+, and ferric, Fe3+) …