Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants

AT Jan, M Azam, K Siddiqui, A Ali, I Choi… - International journal of …, 2015 - mdpi.com
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

Lipoic acid–biological activity and therapeutic potential

A Gorąca, H Huk-Kolega, A Piechota… - Pharmacological …, 2011 - Elsevier
Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid

H Moini, L Packer, NEL Saris - Toxicology and applied pharmacology, 2002 - Elsevier
Reactive oxygen (ROS) and nitrogen oxide (RNOS) species are produced as by-products of
oxidative metabolism. A major function for ROS and RNOS is immunological host defense …

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

A Maczurek, K Hager, M Kenklies, M Sharman… - Advanced drug delivery …, 2008 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

L Holmquist, G Stuchbury, K Berbaum, S Muscat… - Pharmacology & …, 2007 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Endogenous antioxidants: a review of their role in oxidative stress

TAF Aguilar, BCH Navarro… - A master regulator of …, 2016 - books.google.com
Oxidative stress (OxS) constitutes a disturbance caused by an imbalance between the
generation of free radicals and antioxidant system, which causes damage to biomole‐-cules …

Renal-protective roles of lipoic acid in kidney disease

SF Kamt, J Liu, LJ Yan - Nutrients, 2023 - mdpi.com
The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious
elements. It also participates in the regulation of blood pressure, maintenance of electrolyte …

Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants

W Dröge - Experimental gerontology, 2002 - Elsevier
Genetic and biochemical studies suggest that free radical-derived reactive oxygen species
play a key role in a common mechanism of aging in many or all animal species. This led to …

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

W Dröge - … Transactions of the Royal Society B …, 2005 - royalsocietypublishing.org
Reactive oxygen species (ROS) are constantly produced in biological tissues and play a
role in various signalling pathways. Abnormally high ROS concentrations cause oxidative …

Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract

T Hummel, S Heilmann, KB Hüttenbriuk - The Laryngoscope, 2002 - Wiley Online Library
Abstract Objectives/Hypothesis The study aimed to investigate the potential therapeutic
effects of α‐lipoic acid in olfactory loss following infections of the upper respiratory tract …