Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …
and anthropogenic sources, are common environmental pollutants. In recent decades, their …
Lipoic acid–biological activity and therapeutic potential
A Gorąca, H Huk-Kolega, A Piechota… - Pharmacological …, 2011 - Elsevier
Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …
Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid
H Moini, L Packer, NEL Saris - Toxicology and applied pharmacology, 2002 - Elsevier
Reactive oxygen (ROS) and nitrogen oxide (RNOS) species are produced as by-products of
oxidative metabolism. A major function for ROS and RNOS is immunological host defense …
oxidative metabolism. A major function for ROS and RNOS is immunological host defense …
Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease
A Maczurek, K Hager, M Kenklies, M Sharman… - Advanced drug delivery …, 2008 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …
memory and cognition, communication ability with the social environment and the ability to …
Lipoic acid as a novel treatment for Alzheimer's disease and related dementias
L Holmquist, G Stuchbury, K Berbaum, S Muscat… - Pharmacology & …, 2007 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …
memory and cognition, communication ability with the social environment and the ability to …
Endogenous antioxidants: a review of their role in oxidative stress
TAF Aguilar, BCH Navarro… - A master regulator of …, 2016 - books.google.com
Oxidative stress (OxS) constitutes a disturbance caused by an imbalance between the
generation of free radicals and antioxidant system, which causes damage to biomole‐-cules …
generation of free radicals and antioxidant system, which causes damage to biomole‐-cules …
Renal-protective roles of lipoic acid in kidney disease
SF Kamt, J Liu, LJ Yan - Nutrients, 2023 - mdpi.com
The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious
elements. It also participates in the regulation of blood pressure, maintenance of electrolyte …
elements. It also participates in the regulation of blood pressure, maintenance of electrolyte …
Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants
W Dröge - Experimental gerontology, 2002 - Elsevier
Genetic and biochemical studies suggest that free radical-derived reactive oxygen species
play a key role in a common mechanism of aging in many or all animal species. This led to …
play a key role in a common mechanism of aging in many or all animal species. This led to …
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?
W Dröge - … Transactions of the Royal Society B …, 2005 - royalsocietypublishing.org
Reactive oxygen species (ROS) are constantly produced in biological tissues and play a
role in various signalling pathways. Abnormally high ROS concentrations cause oxidative …
role in various signalling pathways. Abnormally high ROS concentrations cause oxidative …
Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract
T Hummel, S Heilmann, KB Hüttenbriuk - The Laryngoscope, 2002 - Wiley Online Library
Abstract Objectives/Hypothesis The study aimed to investigate the potential therapeutic
effects of α‐lipoic acid in olfactory loss following infections of the upper respiratory tract …
effects of α‐lipoic acid in olfactory loss following infections of the upper respiratory tract …