Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Abstract The Nomenclature Committee of the International Society of Amyloidosis (ISA) met
during the XVth Symposium of the Society, 3 July–7 July 2016, Uppsala, Sweden, to assess …

The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …

Inactivation of the transcription factor p53, through either direct mutation or aberrations in
one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years …

For several decades scientists have speculated that the key to understanding age-related
neurodegenerative disorders may be found in the unusual biology of the prion diseases …

In the past fifteen years, it has become apparent that tumour-associated p53 mutations can
provoke activities that are different to those resulting from simply loss of wild-type tumour …

Effective protein quality control (PQC), essential for cellular health, relies on spatial
sequestration of misfolded proteins into defined inclusions. Here we reveal the coordination …

Protein quality control systems are crucial for cellular function and organismal health. At
present, most known protein quality control systems are multicomponent machineries that …