Infection burdens and virulence under heat stress: ecological and evolutionary considerations

TE Hector, ALM Gehman… - … Transactions of the …, 2023 - royalsocietypublishing.org
As a result of global change, hosts and parasites (including pathogens) are experiencing
shifts in their thermal environment. Despite the importance of heat stress tolerance for host …

The evolution of powerful yet perilous immune systems

AL Graham, EC Schrom, CJE Metcalf - Trends in immunology, 2022 - cell.com
The mammalian immune system packs serious punch against infection but can also cause
harm: for example, coronavirus disease 2019 (COVID-19) made headline news of the …

Tripartite interactions: How immunity, microbiota and pathogens interact and affect pathogen virulence evolution

SAO Armitage, E Genersch, DP McMahon… - Current opinion in insect …, 2022 - Elsevier
Highlights•Tripartite interactions occur between hosts, their microbiota, and pathogens.•
Competitive and non-competitive interactions can affect pathogen virulence.•The insect …

Why leveraging sex differences in immune trade‐offs may illuminate the evolution of senescence

CJE Metcalf, O Roth, AL Graham - Functional Ecology, 2020 - Wiley Online Library
The immune system affects senescence (declines in probabilities of survival or reproduction
with age), by shaping late age vulnerability to chronic inflammatory diseases and infections …

Optimal foraging in seasonal environments: implications for residency of Australian flying foxes in food-subsidized urban landscapes

DJ Páez, O Restif, P Eby… - … Transactions of the …, 2018 - royalsocietypublishing.org
Bats provide important ecosystem services such as pollination of native forests; they are also
a source of zoonotic pathogens for humans and domestic animals. Human-induced changes …

Balancing sensitivity, risk, and immunopathology in immune regulation

BP Lazzaro, AT Tate - Current opinion in insect science, 2022 - Elsevier
Highlights•Energetic demands and immunopathology contribute to costs of immunity.•Hosts
must titrate immune responses appropriately to maintain health and fitness in the face of …

The evolution of constitutive and induced defences to infectious disease

M Boots, A Best - Proceedings of the Royal Society B …, 2018 - royalsocietypublishing.org
In response to infectious disease, hosts typically mount both constitutive and induced
defences. Constitutive defence prevents infection in the first place, while induced defence …

An introduction to ecoimmunology

LA Schoenle, CJ Downs, LB Martin - Advances in comparative …, 2018 - Springer
Ecoimmunology is the study of the causes and consequences of variation in immunity. This
integrative field builds on and complements comparative immunology by evaluating …

A genotypic trade-off between constitutive resistance to viral infection and host growth rate

LJ Bartlett, L Wilfert, M Boots - Evolution, 2018 - academic.oup.com
Genotypic trade-offs are fundamental to the understanding of the evolution of life-history
traits. In particular, the evolution of optimal host defense and the maintenance of variation in …

Schedule and magnitude of reproductive investment under immune trade-offs explains sex differences in immunity

CJE Metcalf, AL Graham - Nature Communications, 2018 - nature.com
Sex differences in immunity are found in many species. Known immune mechanisms in
birds and mammals suggest that pathogen detection may be amplified in females, whereas …