Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Homocysteine and age-associated disorders
EA Ostrakhovitch, S Tabibzadeh - Ageing research reviews, 2019 - Elsevier
There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …
[HTML][HTML] H2S biosynthesis and catabolism: new insights from molecular studies
Hydrogen sulfide (H 2 S) has profound biological effects within living organisms and is now
increasingly being considered alongside other gaseous signalling molecules, such as nitric …
increasingly being considered alongside other gaseous signalling molecules, such as nitric …
Vascular complications of cystathionine β-synthase deficiency: Future directions for homocysteine-to-hydrogen sulfide research
RS Beard Jr, SE Bearden - American Journal of Physiology …, 2011 - journals.physiology.org
Homocysteine (Hcy), a cardiovascular and neurovascular disease risk factor, is converted to
hydrogen sulfide (H2S) through the transsulfuration pathway. H2S has attracted …
hydrogen sulfide (H2S) through the transsulfuration pathway. H2S has attracted …
Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen …
I Ueki, HB Roman, A Valli… - American Journal …, 2011 - journals.physiology.org
Cysteine homeostasis is dependent on the regulation of cysteine dioxygenase (CDO) in
response to changes in sulfur amino acid intake. CDO oxidizes cysteine to cysteinesulfinate …
response to changes in sulfur amino acid intake. CDO oxidizes cysteine to cysteinesulfinate …
Gasping for sulfide: A critical appraisal of hydrogen sulfide in lung disease and accelerated aging
Hydrogen sulfide (H2S) is a gaseous signaling molecule involved in a plethora of
physiological and pathological processes. It is primarily synthesized by cystathionine-β …
physiological and pathological processes. It is primarily synthesized by cystathionine-β …
[HTML][HTML] Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/ H2S Pathway
F Talaei, HR Bouma, AC Van der Graaf, AM Strijkstra… - PLoS …, 2011 - journals.plos.org
Biogenic amines have been demonstrated to protect cells from apoptotic cell death. Herein
we show for the first time that serotonin and dopamine increase H2S production by the …
we show for the first time that serotonin and dopamine increase H2S production by the …
[HTML][HTML] A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that …
KN Maclean, J Sikora, V Kožich, H Jiang… - Molecular Genetics and …, 2010 - Elsevier
Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and
serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase …
serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase …
Hydrogen sulfide attenuates paraquat‐induced epithelial‐mesenchymal transition of human alveolar epithelial cells through regulating transforming growth factor‐β1 …
YW Bai, MJ Ye, DL Yang, MP Yu… - Journal of Applied …, 2019 - Wiley Online Library
Exogenous H2S donor, sodium hydrosulfide (NaHS), can influence the bleomycin‐induced
pulmonary fibrosis by attenuating the epithelial‐mesenchymal transition (EMT) of alveolar …
pulmonary fibrosis by attenuating the epithelial‐mesenchymal transition (EMT) of alveolar …
Cardiopulmonary, histologic, and inflammatory effects of intravenous Na2S after blunt chest trauma-induced lung contusion in mice
F Wagner, A Scheuerle, S Weber, B Stahl… - Journal of Trauma …, 2011 - journals.lww.com
Background: When used as a pretreatment, hydrogen sulfide (H 2 S) either attenuated or
aggravated lung injury. Therefore, we tested the hypothesis whether posttreatment …
aggravated lung injury. Therefore, we tested the hypothesis whether posttreatment …