Mechanisms of metastasis in colorectal cancer and metastatic organotropism: hematogenous versus peritoneal spread

E Pretzsch, F Bösch, J Neumann… - Journal of …, 2019 - Wiley Online Library
Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Progress in treatments for colorectal cancer peritoneal metastases during the years 2010–2015. A systematic review

D Baratti, S Kusamura, F Pietrantonio, M Guaglio… - Critical reviews in …, 2016 - Elsevier
Peritoneal metastases (PM) from colorectal cancer (CRC) were traditionally associated with
bad prognosis. Only recently, cytoreductive surgery (CRS) with hyperthermic intraperitoneal …

[HTML][HTML] Molecular characterization of colorectal cancer related peritoneal metastatic disease

KJ Lenos, S Bach, L Ferreira Moreno… - Nature …, 2022 - nature.com
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases
(PM) in the course of their disease. PMs are associated with a poor quality of life, significant …

Carcinoma‐associated fibroblasts derive from mesothelial cells via mesothelial‐to‐mesenchymal transition in peritoneal metastasis

P Sandoval, JA Jiménez‐Heffernan… - The Journal of …, 2013 - Wiley Online Library
Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and
gastrointestinal tract. Tumour cells metastasize by attaching to and invading through the …

Cytoreductive surgery and HIPEC for peritoneal metastases combined with curative treatment of colorectal liver metastases: systematic review of all literature and …

EMV De Cuba, R Kwakman, DL Knol, HJ Bonjer… - Cancer treatment …, 2013 - Elsevier
OBJECTIVE: Assess the overall outcome in colorectal cancer (CRC) patients that present
with a combination of peritoneal metastases (PM) and liver metastases (CRLM) after …

[HTML][HTML] The mesothelial origin of carcinoma associated-fibroblasts in peritoneal metastasis

A Rynne-Vidal, JA Jiménez-Heffernan… - Cancers, 2015 - mdpi.com
Solid tumors are complex and unstructured organs that, in addition to cancer cells, also
contain other cell types. Carcinoma-associated fibroblasts (CAFs) represent an important …

[HTML][HTML] CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells

M Lepsenyi, N Algethami, AA Al-Haidari… - Clinical & experimental …, 2021 - Springer
Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present
study was to define mechanisms regulating colon cancer cell adhesion and spread to …

[HTML][HTML] Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options

N Sluiter, E de Cuba, R Kwakman, G Kazemier… - Clinical & experimental …, 2016 - Springer
Peritoneal dissemination is diagnosed in 10–25% of colorectal cancer patients. Selected
patients are treated with cytoreductive surgery and hyperthermic intraperitoneal …

Patterns of recurrence following complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis of …

HJ Braam, TR Van Oudheusden… - Journal of surgical …, 2014 - Wiley Online Library
Abstract Background and Objectives CytoReductive Surgery (CRS) combined with
Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) has an established role in the …

[HTML][HTML] Risk of metachronous peritoneal metastases in patients with pT4a versus pT4b colon cancer: an international multicentre cohort study

VP Bastiaenen, AGJ Aalbers, A Arjona-Sánchez… - European Journal of …, 2021 - Elsevier
Introduction With evolving treatment strategies aiming at prevention or early detection of
metachronous peritoneal metastases (PM), identification of high-risk colon cancer patients …