The role of regulatory variation in complex traits and disease

FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Natural variations and genome-wide association studies in crop plants

X Huang, B Han - Annual review of plant biology, 2014 - annualreviews.org
Natural variants of crops are generated from wild progenitor plants under both natural and
human selection. Diverse crops that are able to adapt to various environmental conditions …

Learning from co-expression networks: possibilities and challenges

EAR Serin, H Nijveen, HWM Hilhorst… - Frontiers in plant …, 2016 - frontiersin.org
Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …

A framework for understanding gene expression plasticity and its influence on stress tolerance

HE Rivera, HE Aichelman, JE Fifer… - Molecular …, 2021 - Wiley Online Library
Phenotypic plasticity can serve as a stepping stone towards adaptation. Recently, studies
have shown that gene expression contributes to emergent stress responses such as thermal …

Comparative analysis of proteome and transcriptome variation in mouse

A Ghazalpour, B Bennett, VA Petyuk, L Orozco… - PLoS …, 2011 - journals.plos.org
The relationships between the levels of transcripts and the levels of the proteins they encode
have not been examined comprehensively in mammals, although previous work in plants …

Multiple reference genomes and transcriptomes for Arabidopsis thaliana

X Gan, O Stegle, J Behr, JG Steffen, P Drewe… - Nature, 2011 - nature.com
Genetic differences between Arabidopsis thaliana accessions underlie the plant's extensive
phenotypic variation, and until now these have been interpreted largely in the context of the …

Mapping regulatory variants controlling gene expression in drought response and tolerance in maize

S Liu, C Li, H Wang, S Wang, S Yang, X Liu, J Yan, B Li… - Genome biology, 2020 - Springer
Background Gene expression is a key determinant of cellular response. Natural variation in
gene expression bridges genetic variation to phenotypic alteration. Identification of the …

The development of Arabidopsis as a model plant

M Koornneef, D Meinke - The plant journal, 2010 - Wiley Online Library
Twenty‐five years ago, Arabidopsis thaliana emerged as the model organism of choice for
research in plant biology. A consensus was reached about the need to focus on a single …

Mapping complex disease traits with global gene expression

W Cookson, L Liang, G Abecasis, M Moffatt… - Nature Reviews …, 2009 - nature.com
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Metabolomics for functional genomics, systems biology, and biotechnology

K Saito, F Matsuda - Annual review of plant biology, 2010 - annualreviews.org
Metabolomics now plays a significant role in fundamental plant biology and applied
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …