The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Natural variations and genome-wide association studies in crop plants
X Huang, B Han - Annual review of plant biology, 2014 - annualreviews.org
Natural variants of crops are generated from wild progenitor plants under both natural and
human selection. Diverse crops that are able to adapt to various environmental conditions …
human selection. Diverse crops that are able to adapt to various environmental conditions …
Learning from co-expression networks: possibilities and challenges
EAR Serin, H Nijveen, HWM Hilhorst… - Frontiers in plant …, 2016 - frontiersin.org
Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …
organization, function and evolution of plant genes is essential to disentangle important …
A framework for understanding gene expression plasticity and its influence on stress tolerance
Phenotypic plasticity can serve as a stepping stone towards adaptation. Recently, studies
have shown that gene expression contributes to emergent stress responses such as thermal …
have shown that gene expression contributes to emergent stress responses such as thermal …
Comparative analysis of proteome and transcriptome variation in mouse
The relationships between the levels of transcripts and the levels of the proteins they encode
have not been examined comprehensively in mammals, although previous work in plants …
have not been examined comprehensively in mammals, although previous work in plants …
Multiple reference genomes and transcriptomes for Arabidopsis thaliana
Genetic differences between Arabidopsis thaliana accessions underlie the plant's extensive
phenotypic variation, and until now these have been interpreted largely in the context of the …
phenotypic variation, and until now these have been interpreted largely in the context of the …
Mapping regulatory variants controlling gene expression in drought response and tolerance in maize
Background Gene expression is a key determinant of cellular response. Natural variation in
gene expression bridges genetic variation to phenotypic alteration. Identification of the …
gene expression bridges genetic variation to phenotypic alteration. Identification of the …
The development of Arabidopsis as a model plant
M Koornneef, D Meinke - The plant journal, 2010 - Wiley Online Library
Twenty‐five years ago, Arabidopsis thaliana emerged as the model organism of choice for
research in plant biology. A consensus was reached about the need to focus on a single …
research in plant biology. A consensus was reached about the need to focus on a single …
Mapping complex disease traits with global gene expression
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
Metabolomics for functional genomics, systems biology, and biotechnology
Metabolomics now plays a significant role in fundamental plant biology and applied
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …
biotechnology. Plants collectively produce a huge array of chemicals, far more than are …