Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

Templated DNA repair that occurs during homologous recombination and replication stress
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …

Homologous recombination (HR) is a crucial pathway for double-stranded DNA break (DSB)
repair. During the early stages of HR, the newly generated DSB ends are processed to yield …

Cohesins, which mediate sister chromatin cohesion, and CTCF, which functions at
chromatin boundaries, play key roles in the structural and functional organization of …

Fanconi anaemia (FA) is a hereditary disease featuring hypersensitivity to DNA cross-linker-
induced chromosomal instability in association with developmental abnormalities, bone …

Homologous recombination (HR) is essential for error-free repair of DNA double-strand
breaks, perturbed replication forks (RFs), and post-replicative single-stranded DNA (ssDNA) …

Homologous recombination is a high-fidelity DNA repair pathway. Besides a critical role in
accurate chromosome segregation during meiosis, recombination functions in DNA repair …

Escherichia coli RecA is the defining member of a ubiquitous class of DNA strand-exchange
proteins that are essential for homologous recombination, a pathway that maintains genomic …

The central catalyst in eukaryotic ATP-dependent homologous recombination consists of
RAD51 proteins, polymerized around single-stranded DNA. This nucleoprotein filament …