Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
Recent Advances and Future Directions on Small Molecule VEGFR Inhibitors in Oncological Conditions
A Thakur, M Rana, A Mishra, C Kaur, CH Pan… - European Journal of …, 2024 - Elsevier
ABSTRACT “A journey of mixed emotions” is a quote that best describes the progress chart
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
of vascular endothelial growth factor receptor (VEGFR) inhibitors as cancer therapeutics in …
Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity
Two series of pyrazoline compounds were designed and synthesized as antiproliferative
agents by VEGFR pathway inhibition. All synthesized compounds were screened by the …
agents by VEGFR pathway inhibition. All synthesized compounds were screened by the …
[HTML][HTML] A magnetic porous organic polymer: catalytic application in the synthesis of hybrid pyridines with indole, triazole and sulfonamide moieties
Herein, the synthesis and characterization of a triazine-based magnetic ionic porous organic
polymer are reported. The structure, morphology, and components of the prepared structure …
polymer are reported. The structure, morphology, and components of the prepared structure …
Inhibition of human cervical cancer development through p53-dependent pathways induced by the specified triple helical β-glucan
S Hu, H Xu, C Xie, Y Meng, X Xu - International Journal of Biological …, 2023 - Elsevier
This study demonstrates that the purified β-glucan (LNT) with a triple helix and relatively
narrow molecular weight distribution, extracted and purified from artificially cultured Lentinus …
narrow molecular weight distribution, extracted and purified from artificially cultured Lentinus …
The inhibitory effects of selenium nanoparticles modified by fructose-enriched polysaccharide from Codonopsis pilosula on HepG2 cells
J Yu, X Dong, J Jiao, S Yu, H Ji, A Liu… - Industrial Crops and …, 2022 - Elsevier
Ethanol volume fraction of 80% was widely applied for polysaccharides precipitation from
Codonopsis pilosula water-leach liquor, while few researches focused on the dissolved …
Codonopsis pilosula water-leach liquor, while few researches focused on the dissolved …
Physicochemical stability of lichenan (Usnea longissima) decorated-selenium nanoparticles for cancer chemoprevention
Z Yang, Y Hu, P Yue, R Tian, H Li, B Lü, G Chen… - Food Bioscience, 2023 - Elsevier
The biological activity of amorphous selenium nanoparticles (SeNPs) was limited by their
poor stability and rapid spontaneous phase transformation. Herein, we prepared amorphous …
poor stability and rapid spontaneous phase transformation. Herein, we prepared amorphous …
Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer …
In the present study, a drug-like molecular hybrid structure between chalcone and
sulfonamide moieties was synthesized and characterized. The structural peculiarities of the …
sulfonamide moieties was synthesized and characterized. The structural peculiarities of the …
Nicotinonitrile as an essential scaffold in medicinal chemistry: an updated review (2015–present)
Many studies have been carried out to find synthetic pathways to nicotinonitriles (3-
cyanopyridines) and their analogs, which has resulted in a substantial amount of knowledge …
cyanopyridines) and their analogs, which has resulted in a substantial amount of knowledge …
3-Substituted-2, 3-dihydrothiazole as a promising scaffold to design EGFR inhibitors
R El-Haggar, SF Hammad, RI Alsantali, MM Alrooqi… - Bioorganic …, 2022 - Elsevier
The overexpression of EGFR has been recognized as the driver mechanism in the
development of several human malignancies and the clinical use of EGFR inhibitors …
development of several human malignancies and the clinical use of EGFR inhibitors …