Chemically-powered swimming and diffusion in the microscopic world

Y Zhang, H Hess - Nature Reviews Chemistry, 2021 - nature.com
The past decade has seen intriguing reports and heated debates concerning the chemically-
driven enhanced motion of objects ranging from small molecules to millimetre-size synthetic …

Synthetic systems powered by biological molecular motors

G Saper, H Hess - Chemical reviews, 2019 - ACS Publications
Biological molecular motors (or biomolecular motors for short) are nature's solution to the
efficient conversion of chemical energy to mechanical movement. In biological systems …

[HTML][HTML] Roadmap for optical tweezers

G Volpe, OM Maragò… - Journal of Physics …, 2023 - iopscience.iop.org
Optical tweezers are tools made of light that enable contactless pushing, trapping, and
manipulation of objects, ranging from atoms to space light sails. Since the pioneering work …

MINFLUX dissects the unimpeded walking of kinesin-1

JO Wirth, L Scheiderer, T Engelhardt, J Engelhardt… - Science, 2023 - science.org
We introduce an interferometric MINFLUX microscope that records protein movements with
up to 1.7 nanometer per millisecond spatiotemporal precision. Such precision has …

Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins

W Hwang, M Karplus - … of the National Academy of Sciences, 2019 - National Acad Sciences
Two mechanisms have been proposed for the function of motor proteins: The power stroke
and the Brownian ratchet. The former refers to generation of a large downhill free energy …

Germanium nanospheres for ultraresolution picotensiometry of kinesin motors

S Sudhakar, MK Abdosamadi, TJ Jachowski, M Bugiel… - Science, 2021 - science.org
INTRODUCTION Cytoskeletal motors drive many essential mechanical processes inside
cells. For example, kinesin motors are key for cell division or vesicle transport. Kinesin-1 …

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

BG Budaitis, S Jariwala, L Rao, Y Yue, D Sept… - Journal of Cell …, 2021 - rupress.org
The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties …

Optical tweezers in single-molecule experiments

A Zaltron, M Merano, G Mistura, C Sada… - The European Physical …, 2020 - epjplus.epj.org
In the last decades, optical tweezers have progressively emerged as a unique tool to
investigate the biophysical world, allowing to manipulate and control forces and movements …

[HTML][HTML] A new class of biological ion-driven rotary molecular motors with 5: 2 symmetry

M Rieu, R Krutyholowa, NMI Taylor… - Frontiers in …, 2022 - frontiersin.org
Several new structures of three types of protein complexes, obtained by cryo-electron
microscopy (cryo-EM) and published between 2019 and 2021, identify a new family of …

[HTML][HTML] The mitotic spindle is chiral due to torques within microtubule bundles

M Novak, B Polak, J Simunić, Z Boban… - Nature …, 2018 - nature.com
Mitosis relies on forces generated in the spindle, a micro-machine composed of
microtubules and associated proteins. Forces are required for the congression of …