Chemically-powered swimming and diffusion in the microscopic world
The past decade has seen intriguing reports and heated debates concerning the chemically-
driven enhanced motion of objects ranging from small molecules to millimetre-size synthetic …
driven enhanced motion of objects ranging from small molecules to millimetre-size synthetic …
Synthetic systems powered by biological molecular motors
Biological molecular motors (or biomolecular motors for short) are nature's solution to the
efficient conversion of chemical energy to mechanical movement. In biological systems …
efficient conversion of chemical energy to mechanical movement. In biological systems …
[HTML][HTML] Roadmap for optical tweezers
Optical tweezers are tools made of light that enable contactless pushing, trapping, and
manipulation of objects, ranging from atoms to space light sails. Since the pioneering work …
manipulation of objects, ranging from atoms to space light sails. Since the pioneering work …
MINFLUX dissects the unimpeded walking of kinesin-1
JO Wirth, L Scheiderer, T Engelhardt, J Engelhardt… - Science, 2023 - science.org
We introduce an interferometric MINFLUX microscope that records protein movements with
up to 1.7 nanometer per millisecond spatiotemporal precision. Such precision has …
up to 1.7 nanometer per millisecond spatiotemporal precision. Such precision has …
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins
W Hwang, M Karplus - … of the National Academy of Sciences, 2019 - National Acad Sciences
Two mechanisms have been proposed for the function of motor proteins: The power stroke
and the Brownian ratchet. The former refers to generation of a large downhill free energy …
and the Brownian ratchet. The former refers to generation of a large downhill free energy …
Germanium nanospheres for ultraresolution picotensiometry of kinesin motors
S Sudhakar, MK Abdosamadi, TJ Jachowski, M Bugiel… - Science, 2021 - science.org
INTRODUCTION Cytoskeletal motors drive many essential mechanical processes inside
cells. For example, kinesin motors are key for cell division or vesicle transport. Kinesin-1 …
cells. For example, kinesin motors are key for cell division or vesicle transport. Kinesin-1 …
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms
The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties …
facilitates long-distance transport, but little is known about its force-generating properties …
Optical tweezers in single-molecule experiments
In the last decades, optical tweezers have progressively emerged as a unique tool to
investigate the biophysical world, allowing to manipulate and control forces and movements …
investigate the biophysical world, allowing to manipulate and control forces and movements …
[HTML][HTML] A new class of biological ion-driven rotary molecular motors with 5: 2 symmetry
Several new structures of three types of protein complexes, obtained by cryo-electron
microscopy (cryo-EM) and published between 2019 and 2021, identify a new family of …
microscopy (cryo-EM) and published between 2019 and 2021, identify a new family of …
[HTML][HTML] The mitotic spindle is chiral due to torques within microtubule bundles
Mitosis relies on forces generated in the spindle, a micro-machine composed of
microtubules and associated proteins. Forces are required for the congression of …
microtubules and associated proteins. Forces are required for the congression of …