Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery

S Ekins, JS Freundlich, I Choi, M Sarker, C Talcott - Trends in microbiology, 2011 - cell.com
We are witnessing the growing menace of both increasing cases of drug-sensitive and drug-
resistant Mycobacterium tuberculosis strains and the challenge to produce the first new …

Comparative proteomic investigation unravels the pathobiology of Mycobacterium fortuitum biofilm

A Sharma, S Bansal, N Kumari, J Vashistt… - Applied Microbiology …, 2023 - Springer
Biofilm formation by Mycobacterium fortuitum causes serious threats to human health due to
its increased contribution to nosocomial infections. In this study, the first comprehensive …

Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism

S Nambi, K Gupta, M Bhattacharyya… - Journal of Biological …, 2013 - ASBMB
Acetylation of lysine residues is a posttranslational modification that is used by both
eukaryotes and prokaryotes to regulate a variety of biological processes. Here we identify …

Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: homology modeling, docking, and molecular dynamics study

D Pradhan, V Priyadarshini, M Munikumar… - Journal of …, 2014 - Taylor & Francis
Leptospira interrogans, a Gram-negative bacterial pathogen is the main cause of human
leptospirosis. Lipid A is a highly immunoreactive endotoxic center of lipopolysaccharide …

Targeting Mycobacterium tuberculosis tumor necrosis factor alpha-downregulating genes for the development of antituberculous vaccines

A Olsen, Y Chen, Q Ji, G Zhu, AD De Silva, C Vilchèze… - MBio, 2016 - Am Soc Microbiol
Tumor necrosis factor alpha (TNF) plays a critical role in the control of Mycobacterium
tuberculosis, in part by augmenting T cell responses through promoting macrophage …

The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme

CS Andersson, CAK Lundgren, A Magnúsdóttir, C Ge… - Structure, 2012 - cell.com
The Mycobacterium tuberculosis acid-induced operon MymA encodes the fatty acyl-CoA
synthetase FadD13 and is essential for virulence and intracellular growth of the pathogen …

Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis

V Priyadarshini, D Pradhan, M Munikumar… - Journal of …, 2014 - Taylor & Francis
Infective endocarditis (IE) has emerged as a public health problem due to changes in the
etiologic spectrum and due to involvement of resistant bacterial strains with increased …

Exploring the inhibitory potential of bioactive compound from Luffa acutangula against NF-κB—a molecular docking and dynamics approach

V Ramar, S Pappu - Computational biology and chemistry, 2016 - Elsevier
Nuclear factor kappa B (NF-κB) is a transcription factor, plays a crucial role in the regulation
of various physiological processes such as differentiation, cell proliferation and apoptosis. It …

Systematic identification of Mycobacterium tuberculosis effectors reveals that BfrB suppresses innate immunity

X He, H Jiang, H Chen, H Zhang, Y Liu, Z Xu… - Molecular & Cellular …, 2017 - ASBMB
Mycobacterium tuberculosis (Mtb) has evolved multiple strategies to counter the human
immune system. The effectors of Mtb play important roles in the interactions with the host …

Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis

JY Xu, L Zhao, XX Liu, H Hu, P Liu, M Tan… - ACS Chemical …, 2018 - ACS Publications
Protein acylation plays important roles in bacterial pathogenesis through regulation of
enzymatic activity, protein stability, nucleic acid binding ability, and protein–protein …