Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery
We are witnessing the growing menace of both increasing cases of drug-sensitive and drug-
resistant Mycobacterium tuberculosis strains and the challenge to produce the first new …
resistant Mycobacterium tuberculosis strains and the challenge to produce the first new …
Comparative proteomic investigation unravels the pathobiology of Mycobacterium fortuitum biofilm
Biofilm formation by Mycobacterium fortuitum causes serious threats to human health due to
its increased contribution to nosocomial infections. In this study, the first comprehensive …
its increased contribution to nosocomial infections. In this study, the first comprehensive …
Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism
Acetylation of lysine residues is a posttranslational modification that is used by both
eukaryotes and prokaryotes to regulate a variety of biological processes. Here we identify …
eukaryotes and prokaryotes to regulate a variety of biological processes. Here we identify …
Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: homology modeling, docking, and molecular dynamics study
D Pradhan, V Priyadarshini, M Munikumar… - Journal of …, 2014 - Taylor & Francis
Leptospira interrogans, a Gram-negative bacterial pathogen is the main cause of human
leptospirosis. Lipid A is a highly immunoreactive endotoxic center of lipopolysaccharide …
leptospirosis. Lipid A is a highly immunoreactive endotoxic center of lipopolysaccharide …
Targeting Mycobacterium tuberculosis tumor necrosis factor alpha-downregulating genes for the development of antituberculous vaccines
A Olsen, Y Chen, Q Ji, G Zhu, AD De Silva, C Vilchèze… - MBio, 2016 - Am Soc Microbiol
Tumor necrosis factor alpha (TNF) plays a critical role in the control of Mycobacterium
tuberculosis, in part by augmenting T cell responses through promoting macrophage …
tuberculosis, in part by augmenting T cell responses through promoting macrophage …
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme
CS Andersson, CAK Lundgren, A Magnúsdóttir, C Ge… - Structure, 2012 - cell.com
The Mycobacterium tuberculosis acid-induced operon MymA encodes the fatty acyl-CoA
synthetase FadD13 and is essential for virulence and intracellular growth of the pathogen …
synthetase FadD13 and is essential for virulence and intracellular growth of the pathogen …
Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis
V Priyadarshini, D Pradhan, M Munikumar… - Journal of …, 2014 - Taylor & Francis
Infective endocarditis (IE) has emerged as a public health problem due to changes in the
etiologic spectrum and due to involvement of resistant bacterial strains with increased …
etiologic spectrum and due to involvement of resistant bacterial strains with increased …
Exploring the inhibitory potential of bioactive compound from Luffa acutangula against NF-κB—a molecular docking and dynamics approach
V Ramar, S Pappu - Computational biology and chemistry, 2016 - Elsevier
Nuclear factor kappa B (NF-κB) is a transcription factor, plays a crucial role in the regulation
of various physiological processes such as differentiation, cell proliferation and apoptosis. It …
of various physiological processes such as differentiation, cell proliferation and apoptosis. It …
Systematic identification of Mycobacterium tuberculosis effectors reveals that BfrB suppresses innate immunity
X He, H Jiang, H Chen, H Zhang, Y Liu, Z Xu… - Molecular & Cellular …, 2017 - ASBMB
Mycobacterium tuberculosis (Mtb) has evolved multiple strategies to counter the human
immune system. The effectors of Mtb play important roles in the interactions with the host …
immune system. The effectors of Mtb play important roles in the interactions with the host …
Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis
JY Xu, L Zhao, XX Liu, H Hu, P Liu, M Tan… - ACS Chemical …, 2018 - ACS Publications
Protein acylation plays important roles in bacterial pathogenesis through regulation of
enzymatic activity, protein stability, nucleic acid binding ability, and protein–protein …
enzymatic activity, protein stability, nucleic acid binding ability, and protein–protein …