Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

Microglia are the predominant immune cells of the central nervous system (CNS) that exert
key physiological roles required for maintaining CNS homeostasis, notably in response to …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …

Alzheimer's disease (AD) is the world's most common dementing illness, affecting over 150
million patients. Classically AD has been viewed as a neurodegenerative disease of the …

Neuroinflammation is an important contributor to Alzheimer9s disease (AD) pathogenesis,
as underscored by the recent identification of immune-related genetic risk factors for AD …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare …

The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that
regulates innate immunity but has no known functions in the brain. We have previously …

Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a
crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide …