Stem cells have emerged as a key element of regenerative medicine therapies due to their
inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous …

(excepting mitochondrially encoded genes). The second was the notion that adult cells, and
adult stem cells in particular, might have a greater ability to differentiate into other cell types …

BACKGROUND: There are several reports that engrafted mesenchymal stem cells (MSCs)
stimulate angiogenesis in the ischemic heart, but the mechanism remains controversial. We …

OBJECTIVE: Direct intramyocardial injection is a common route of donor cell administration
for myocardial cell therapy. Studies have demonstrated a significant and rapid loss of …

We aimed to optimize non-viral transfection of human stromal cell derived factor (SDF-1α)
gene into skeletal myoblasts (SkM) and, transplant these cells to establish transient SDF-1α …

Inadequate extracellular matrix cues and subsequent apoptotic cell death are among crucial
factors currently limiting cell viability and organ retention in cell-based therapeutic strategies …

BACKGROUND: Left ventricular (LV) remodeling after myocardial infarction (MI) commonly
causes infarct expansion (IE). This study sought to interrupt IE through microinjections of a …

We postulated that combining cell based hVEGF165 gene delivery with cytokine-induced
mobilization of bone marrow cells (BMC) may give better prognosis in an infarcted heart …

Cell therapy has the potential to improve healing of ischemic heart, repopulate injured
myocardium and restore cardiac function. The tremendous hope and potential of stem cell …

Background—After a myocardial infarction, the injured region becomes fibrotic and the
myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may …