Antiviral and Immunomodulatory Effects of Interferon Lambda at the Maternal-Fetal Interface

MR Dedloff, HM Lazear - Annual Review of Virology, 2024 - annualreviews.org
Interferon lambda (IFN-λ, type III IFN, IL-28/29) is a family of antiviral cytokines that are
especially important at barrier sites, including the maternal-fetal interface. Recent …

A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model

CM McMillen, NS Chapman, RM Hoehl… - Nature …, 2023 - nature.com
Rift Valley fever virus (RVFV) is an emerging mosquito-transmitted virus that circulates in
livestock and humans in Africa and the Middle East. Outbreaks lead to high rates of …

Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice

MM Schwarz, SS Ganaie, A Feng, G Brown… - Science …, 2023 - science.org
Rift Valley fever virus (RVFV) is an emerging arbovirus found in Africa. While RVFV is
pantropic and infects many cells and tissues, viral replication and necrosis within the liver …

Arboviruses and pregnancy: are the threats visible or hidden?

N Hcini, V Lambert, O Picone, JF Carod… - Tropical diseases, travel …, 2024 - Springer
Mosquito-borne arboviral diseases are a global concern and can have severe
consequences on maternal, neonatal, and child health. Their impact on pregnancy tends to …

Alternative Splicing of RIOK3 Engages the Noncanonical NFκB Pathway during Rift Valley Fever Virus Infection

TC Bisom, H Smelser, JM Lanchy, JS Lodmell - Viruses, 2023 - mdpi.com
Although the noncanonical NFκB pathway was originally identified as a cellular pathway
contributing to lymphoid organogenesis, in the past 20 years, its involvement in innate …

Acute Rift Valley fever virus infection induces inflammatory cytokines and cell death in ex vivo rat brain slice culture

KA Connors, ZD Frey, MJ Demers… - Journal of General …, 2024 - microbiologyresearch.org
Rift Valley fever virus (RVFV) is an emerging arboviral disease with pandemic potential.
While infection is often self-limiting, a subset of individuals may develop late-onset …

Dissecting Rubella Placental Infection in an In Vitro Trophoblast Model

J Schulz, E Schilling, C Fabian, AC Zenclussen… - International Journal of …, 2023 - mdpi.com
Vertical transmission of rubella virus (RuV) occurs at a high rate during the first trimester of
pregnancy. The modes of vertical transmission including the response of trophoblasts to …

Laboratory Animal Models for Rift Valley Fever Virus Disease

TL Freeman, AK McElroy - Rift Valley Fever Virus: Methods and Protocols, 2024 - Springer
Rift Valley fever virus (RVFV) is an arboviral pathogen of clinical and agricultural relevance.
The ongoing development of targeted RVFV prophylactics and therapeutics is …

Characterization of neural infection by Oropouche orthobunyavirus

KA Connors, MR Pedlow, ZD Frey, JJ McGaughey… - bioRxiv, 2024 - biorxiv.org
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche
orthobunyavirus (OROV). While disease is generally self-limiting, historical and recent …

Oropouche virus infects human placenta explants and trophoblast organoids

C Megli, RK Zack, J McGaughey, RM Hoehl, T Snisky… - bioRxiv, 2024 - biorxiv.org
Clinical and epidemiologic evidence from the recent outbreak of Oropouche virus (OROV)
has demonstrated increased severity in clinical disease and adverse pregnancy outcomes …