Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss

S Pouwels, N Sakran, Y Graham, A Leal, T Pintar… - BMC endocrine …, 2022 - Springer
Given the increasing prevalence of diabetes and obesity worldwide, the deleterious effects
of non-alcoholic fatty liver disease (NAFLD) are becoming a growing challenge for public …

Nonalcoholic fatty liver disease and cardiovascular risk: a scientific statement from the American Heart Association

PB Duell, FK Welty, M Miller, A Chait… - … , and vascular biology, 2022 - Am Heart Assoc
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is
believed to affect> 25% of adults worldwide. Unless specific testing is done to identify …

Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study

R Nahra, T Wang, KM Gadde, J Oscarsson… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Cotadutide, a dual GLP-1 and glucagon receptor agonist, is under development
for nonalcoholic steatohepatitis (NASH) and chronic kidney disease with type 2 diabetes …

Nonalcoholic fatty liver disease 2020: the state of the disease

TG Cotter, M Rinella - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, with a worldwide
prevalence of 25%. In the United States, NAFLD and its subtype, nonalcoholic …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

MAFLD: A multisystem disease

RM Pipitone, C Ciccioli, G Infantino… - Therapeutic …, 2023 - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …

[PDF][PDF] Modulation of insulin resistance in nonalcoholic fatty liver disease

RS Khan, F Bril, K Cusi, PN Newsome - Hepatology, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has an estimated prevalence of 25% in the general
population, and cirrhosis secondary to nonalcoholic steatohepatitis (NASH) is predicted to …

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

LA Adams, QM Anstee, H Tilg, G Targher - Gut, 2017 - gut.bmj.com
Key physiological functions of the liver, including glucose and lipid metabolism, become
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …

Hypertension, diabetes, atherosclerosis and NASH: cause or consequence?

A Lonardo, F Nascimbeni, A Mantovani, G Targher - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of
chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD …

NAFLD and diabetes mellitus

H Tilg, AR Moschen, M Roden - Nature reviews Gastroenterology & …, 2017 - nature.com
The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …