Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion.
Osteoblasts are responsible for proper bone formation and remodeling, and function. These …

Osteoporosis is a metabolic bone disease that affects hundreds of millions of people
worldwide and is characterized by excessive loss of bone protein and mineral content. The …

Lysosomal acid lipase deficiency (LAL-D) presents as one of two rare autosomal recessive
diseases: Wolman disease (WD), a severe disorder presenting in infancy characterized by …

Lysosomal acid lipase (LAL) is a lysosomal enzyme essential for the degradation of
cholesteryl esters through the endocytic pathway. Deficiency of the LAL enzyme encoded by …

Bone is a dynamic tissue reshaped by constant bone formation and bone resorption to
maintain its function. The skeletal system accounts for approximately 70% of the total volume …

Strontium is receiving widespread attention due to its remarkable biological qualities in
preventing bone resorption and fostering osteogenesis. However, the chemical processes …

Lipid metabolism is one of energy metabolic pathways that produce adenosine triphosphate
(ATP). In this pathway, lysosomal acid lipase (LAL) encoded by Lipase A (LIPA), plays an …

There has been interest in the connection between cardiovascular diseases and
osteoporosis, both of which share hyperlipidemia as a common pathological basis …

High fat diets overwhelm the physiological mechanisms for absorption, storage, and
utilization of triglycerides (TG); consequently TG, TG‐rich lipoproteins (TGRL), and TGRL …

Introduction Lysosomal acid lipase deficiency disease (LALD; MIM# 278000) is an ultrarare
lysosomal storage disease with a wide range of phenotypic variability. It is caused by the …