Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins
characterized by four transmembrane domains. They participate in a variety of cellular …

The first tetraspanins were discovered on surface of human leucocytes, but it was rapidly
demonstrated that they had a wider tissue expression. Twenty-six molecules display …

Cutaneous malignant melanoma (melanoma) is characterized by a high mutational load,
extensive intertumoral and intratumoral genetic heterogeneity, and complex tumor …

CD82 and CD9 are tetraspanin membrane proteins that can function as suppressors of
tumor metastasis. Expression of CD9 and CD82 in transfected cells strongly suppresses β …

CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily
of proteins. The tetraspanins CD9, KAI-1/CD82, and CD63 are involved in metastasis …

For metastasis to occur cells must communicate with to their local environment to initiate
growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell …

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix
metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the …

Abstract CD9, CD63, CD81, and CD82 are glycoproteins of unknown function which belong
to the tetraspan superfamily. These molecules have short cytoplasmic sequences, four …

Exosomes, a type of extracellular vesicle with a diameter of approximately 100 nm that is
secreted by all cells, regulate the phenotype and function of recipient cells by carrying …