Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …

Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …

Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes
exist. Our aim was to use a unique collection of pancreas samples recovered soon after …

First envisioned by early diabetes clinicians, a person-centred approach to care was an
aspirational goal that aimed to match insulin therapy to each individual's unique …

Histological analysis of donor pancreases coupled with measurement of serum C-peptide in
clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 …

Type 1 Diabetes (T1D) is one of the most common chronic autoimmune diseases in children.
The disease is characterized by the destruction of beta cells, leading to hyperglycemia, and …

FIGURE 1 The stages of type 1 diabetes (T1D)(DiabetesTrialNet. org). A proportion of
individuals who have increased genetic risk of T1D progress at variable rates to immune …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Background Contrary to the presumption that type 1 diabetes leads to an absolute insulin
deficiency, many individuals with type 1 diabetes have circulating C-peptide years after the …