Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

Mutations in the KRAS oncogene are found in more than 90% of patients with pancreatic
ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (KRAS G12D) being the most …

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …