In this review we intend to provide a relatively comprehensive summary of the work of
supramolecular hydrogelators after 2004 and to put emphasis particularly on the …

Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors. The first
two generations of cancer immunotherapy agents consist primarily of antagonist antibodies …

Colloidal aggregation of organic molecules is the dominant mechanism for artifactual
inhibition of proteins, and controls against it are widely deployed. Notwithstanding an …

High-throughput biology has contributed a wealth of data on chemicals, including natural
products (NPs). Recently, attention was drawn to certain, predominantly synthetic …

The central dogma of the action of current anticancer drugs is that the drug tightly binds to its
molecular target for inhibition. The reliance on tight ligand–receptor binding, however, is …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

In this study, we obtained all the homogeneous LBGP70 (arabinogalactan-protein complex),
LBGP70-OL (sugar chain of LBGP70), and LBGP70-OL-I (backbone part of LBGP70-OL) …

It is well known that small molecule colloidal aggregation is a leading cause of false
positives in early drug discovery. Colloid-formers are diverse and well represented among …

Compounds that exhibit assay interference or undesirable mechanisms of bioactivity ("
nuisance compounds") are routinely encountered in cellular assays, including phenotypic …

Demonstrating intracellular protein target engagement is an essential step in the
development and progression of new chemical probes and potential small molecule …