HIV-1 maturation: lessons learned from inhibitors
AB Kleinpeter, EO Freed - Viruses, 2020 - mdpi.com
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …
effective therapies has accompanied a massive increase in our understanding of the …
[HTML][HTML] Retroviral proteases and their roles in virion maturation
J Konvalinka, HG Kräusslich, B Müller - Virology, 2015 - Elsevier
Proteolytic processing of viral polyproteins is essential for retrovirus infectivity. Retroviral
proteases (PR) become activated during or after assembly of the immature, non-infectious …
proteases (PR) become activated during or after assembly of the immature, non-infectious …
Cone-shaped HIV-1 capsids are transported through intact nuclear pores
Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …
uncoating and nuclear import of the viral genome are critical for productive infection. The …
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be …
Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy
J Chojnacki, T Staudt, B Glass, P Bingen, J Engelhardt… - Science, 2012 - science.org
Human immunodeficiency virus type 1 (HIV-1) buds from the cell as an immature particle
requiring subsequent proteolysis of the main structural polyprotein Gag for morphological …
requiring subsequent proteolysis of the main structural polyprotein Gag for morphological …
Neutral sphingomyelinase 2 is required for HIV-1 maturation
HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …
membrane microdomains. The size and stability of membrane microdomains is regulated by …
Assembly and architecture of HIV
BK Ganser-Pornillos, M Yeager, O Pornillos - Viral molecular machines, 2011 - Springer
HIV forms spherical, membrane-enveloped, pleomorphic virions, 1,000–1,500 Å in diameter,
which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles …
which contain two copies of its single-stranded, positive-sense RNA genome. Virus particles …
Novel dengue virus NS2B/NS3 protease inhibitors
H Wu, S Bock, M Snitko, T Berger… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Dengue fever is a severe, widespread, and neglected disease with more than 2 million
diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a …
diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a …
Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance
HIV-1 protease inhibitors (PIs) are among the most effective antiretroviral drugs. They are
characterized by highly cooperative dose-response curves that are not explained by current …
characterized by highly cooperative dose-response curves that are not explained by current …
Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA
Detection of viral DNA by cyclic GMP‐AMP synthase (cGAS) is a first line of defence leading
to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN …
to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN …