NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

CAR-NK cells: A promising cellular immunotherapy for cancer

G Xie, H Dong, Y Liang, JD Ham, R Rizwan, J Chen - EBioMedicine, 2020 - thelancet.com
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Y Gong, RGJ Klein Wolterink, J Wang, GMJ Bos… - Journal of hematology & …, 2021 - Springer
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Natural killer cell therapies

E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

[HTML][HTML] Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti-tumor activity

Y Li, DL Hermanson, BS Moriarity, DS Kaufman - Cell stem cell, 2018 - cell.com
Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …

[HTML][HTML] Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

SM Poznanski, K Singh, TM Ritchie, JA Aguiar, IY Fan… - Cell Metabolism, 2021 - cell.com
NK cells are central to anti-tumor immunity and recently showed efficacy for treating
hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment …

Current perspectives on “off-the-shelf” allogeneic NK and CAR-NK cell therapies

EL Heipertz, ER Zynda, TE Stav-Noraas… - Frontiers in …, 2021 - frontiersin.org
Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …