Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs)
desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated …

The binding complexes formed by proteins and small molecule ligands are ubiquitous and
critical to life. Despite recent advancements in protein structure prediction, existing …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

The human adenosine A2B receptor (A2BR) is a class AG protein–coupled receptor that is
involved in several major physiological and pathological processes throughout the body …

Class BG protein-coupled receptors (GPCRs) are important targets in the treatment of
metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

We introduce a Gaussian-accelerated molecular dynamics (GaMD), deep learning (DL), and
free energy profiling workflow (GLOW) to predict molecular determinants and map free …

The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes
lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T …