Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
Signaling scaffolds, with their ability to bring together proteins belonging to common and/or …

We have investigated the subcellular localization, the domain topology, and the amino acid
residues that are critical for the function of the presumptive Arabidopsis thaliana auxin influx …

The transient receptor potential (TRP) family of ion channels participate in many signaling
pathways. TRPV1 functions as a molecular integrator of noxious stimuli, including heat, low …

After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …

Recent research suggests that in addition to their role as soluble electron carriers, pyridine
nucleotides [NAD (P)(H)] also regulate ion transport mechanisms. This mode of regulation …

Ion channel complexes typically consist of both pore-forming subunits and auxiliary subunits
that do not directly conduct current but can regulate trafficking or alter channel properties …

The basic architecture of the voltage-dependent K+ channels (Kv channels) corresponds to
a transmembrane protein core in which the permeation pore, the voltage-sensing …

The activity of the voltage-sensitive K+ (Kv) channels varies as a function of the intracellular
redox state and metabolism, and several Kv channels act as oxygen sensors. However, the …

The Shaker family voltage-dependent potassium channels (Kv1) assemble with cytosolic β-
subunits (Kvβ) to form a stable complex. All Kvβ subunits have a conserved core domain …