The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Autism spectrum disorders (ASD) and epilepsy are common neurological diseases of
childhood, with an estimated incidence of approximately 0.5–1% of the worldwide …

Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Two apolipoprotein E (apoE) receptors, the very low density lipoprotein (VLDL) receptor and
apoE receptor 2 (apoER2), are also receptors for Reelin, a signaling protein that regulates …

BACKGROUND: A limited number of reports have demonstrated abnormalities involving the
glutamate and gamma amino butyric acid systems in blood and platelets of subjects with …

Autism spectrum disorders (ASD) are male-biased and characterized by deficits in social
behavior and social communication, excessive anxiety or hyperreactivity to stressful …