Colorectal cancer arises through a gradual series of histological changes, each of which is
accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply …

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …

Postreplicative mismatch repair (MMR) increases the fidelity of DNA replication by up to
three orders of magnitude, through correcting DNA polymerase errors that escaped …

Activation of Akt, or protein kinase B, is frequently observed in human cancers. Here we
report that Akt activation via overexpression of a constitutively active form or via the loss of …

The tumor suppressor gene BRCA1 was cloned in 1994 based on its linkage to early-onset
breast and ovarian cancer. Although the BRCA1 protein has been implicated in multiple …

Germline mutations in the tumor suppressor gene BRCA1 predispose women to breast
cancer, however somatic mutations in the gene are rarely detected in sporadic cancers. To …

Background: Neoadjuvant chemotherapy has shown a modest benefit in muscle-invasive
bladder cancer patients; however, the subset of patients most likely to benefit has not been …

BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase
function, is implicated in cellular immortalization. Here, we find that BRIT1 acts as a regulator …

Emerging evidence links the growth hormone (GH)-insulin-like growth factor-1 (IGF1)
endocrine axis to cancer development. While this putative correlation is of major …

A biologically aggressive subset of human breast cancers has been demonstrated to
overexpress fatty acid synthase (FAS), the key enzyme of endogenous FA biosynthesis. This …