Fungal dimorphism and virulence: molecular mechanisms for temperature adaptation, immune evasion, and in vivo survival

GM Gauthier - Mediators of inflammation, 2017 - Wiley Online Library
The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum
that respond to shifts in temperature by converting between hyphae (22–25° C) and yeast …

Role of the fungal cell wall in pathogenesis and antifungal resistance

DF Díaz-Jiménez, LA Pérez-García… - Current Fungal Infection …, 2012 - Springer
Study of the fungal cell wall is currently an area of very active research. The relevance of the
fungal cell wall for cell survival, and pathogenicity has been well established. The view of …

NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis

AH Tavares, KG Magalhães… - PLoS neglected …, 2013 - journals.plos.org
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), the
most prevalent systemic mycosis that is geographically confined to Latin America. The pro …

Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory …

IM Siqueira, RJA de Castro… - PLoS Neglected …, 2017 - journals.plos.org
A common theme across multiple fungal pathogens is their ability to impair the
establishment of a protective immune response. Although early inflammation is beneficial in …

Participation of dectin-1 receptor on NETs release against Paracoccidioides brasiliensis: Role on extracellular killing

TF Bachiega, LA Dias-Melicio, RK Fernandes… - Immunobiology, 2016 - Elsevier
Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which
is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with …

Innate immune receptors and defense against primary pathogenic fungi

TN Kirkland, J Fierer - Vaccines, 2020 - mdpi.com
The innate immune system is critical for natural resistance to all pathogenic microorganisms,
including fungi. The innate response plays a vital role in resistance to infections before the …

Dendritic cell interactions with Histoplasma and Paracoccidioides

SK Thind, CP Taborda, JD Nosanchuk - Virulence, 2015 - Taylor & Francis
Fungi are among the most common microbes encountered by humans. More than 100, 000
fungal species have been described in the environment to date, however only a few species …

Characterization of functional mannose receptor in a continuous hybridoma cell line

DJ Vigerust, S Vick, VL Shepherd - Bmc Immunology, 2012 - Springer
Background The mannose receptor is the best described member of the type I
transmembrane C-type lectins; however much remains unanswered about the biology of the …

Role of Dectin‐1 receptor on cytokine production by human monocytes challenged with Paracoccidioides brasiliensis

AG Romagnolo, JC de Quaglia e Silva… - Mycoses, 2018 - Wiley Online Library
Fungal recognition by Dectin‐1 receptor triggers a series of cellular mechanisms involved in
a protective activation of the immune system. In this study, we aimed to evaluate the …

New Role of P. brasiliensis α-Glucan: Differentiation of Non-conventional Dendritic Cells

ACO Souza, C Favali, NC Soares, NM Tavares… - Frontiers in …, 2019 - frontiersin.org
The cell wall has a critical role in the host immune response to fungal pathogens. In this
study, we investigated the influence of two cell wall fractions of the dimorphic fungi …