Independent drug action in combination therapy: implications for precision oncology
Combination therapies are superior to monotherapy for many cancers. This advantage was
historically ascribed to the ability of combinations to address tumor heterogeneity, but …
historically ascribed to the ability of combinations to address tumor heterogeneity, but …
Recent advances in MOF-based nanoplatforms generating reactive species for chemodynamic therapy
Y Zhong, X Li, J Chen, X Wang, L Wei, L Fang… - Dalton …, 2020 - pubs.rsc.org
Still today, cancer remains a threat to human health. Possible common treatments to cure
this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and …
this disease include chemotherapy (CT), radiotherapy (RT), photothermal therapy (PTT), and …
SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples
Abstract SynergyFinder (https://synergyfinder. fimm. fi) is a free web-application for
interactive analysis and visualization of multi-drug combination response data. Since its first …
interactive analysis and visualization of multi-drug combination response data. Since its first …
SynergyFinder 2.0: visual analytics of multi-drug combination synergies
Abstract SynergyFinder (https://synergyfinder. fimm. fi) is a stand-alone web-application for
interactive analysis and visualization of drug combination screening data. Since its first …
interactive analysis and visualization of drug combination screening data. Since its first …
[HTML][HTML] Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach
Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
Machine learning approaches for drug combination therapies
B Güvenç Paltun, S Kaski… - Briefings in …, 2021 - academic.oup.com
Drug combination therapy is a promising strategy to treat complex diseases such as cancer
and infectious diseases. However, current knowledge of drug combination therapies …
and infectious diseases. However, current knowledge of drug combination therapies …
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
A Ianevski, J Lahtela, KK Javarappa, P Sergeev… - Science …, 2021 - science.org
The extensive drug resistance requires rational approaches to design personalized
combinatorial treatments that exploit patient-specific therapeutic vulnerabilities to selectively …
combinatorial treatments that exploit patient-specific therapeutic vulnerabilities to selectively …
Space station-like composite nanoparticles for co-delivery of multiple natural compounds from chinese medicine and hydrogen in combating sensorineural hearing …
W Xiao, K He, C Yu, Z Zhou, L Xia, S Xie… - Molecular …, 2023 - ACS Publications
Ototoxic drugs such as aminoglycoside antibiotics and cisplatin (CDDP) can cause
sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the …
sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the …