The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Extensively revised, comprehensive content from leading global contributors ensures that
Hematology, 8th Edition, remains your# 1 choice for expert guidance in all areas of this …

Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …

Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

Genomic editing to correct disease-causing mutations is a promising approach for the
treatment of human diseases. As a simple and programmable nuclease-based genomic …

Simple Summary The Notch signaling pathway regulates cell proliferation, apoptosis, stem
cell self-renewal, and differentiation in a context-dependent fashion both during embryonic …

Hereditary antithrombin deficiency is caused by SERPINC1 gene mutations and
predisposes to recurrent venous thromboembolism that can be life-threatening. Therefore …

Congenital coagulopathies have, throughout the history of medicine, been a focus of
scientific study and of great interest as they constitute an alteration of one of the most …