Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

The multiple functions of lysosomes are critically dependent on their ability to undergo
bidirectional movement along microtubules between the center and the periphery of the cell …

Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …

Bardet–Biedl syndrome (BBS) is a rare inherited disease caused by defects in the BBSome,
an octameric complex of BBS proteins. The BBSome is conserved in most organisms with …

Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …

Recent studies have revealed unexpected connections between the mammalian Hedgehog
(Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that …

The primary cilium acts as a transducer of extracellular stimuli into intracellular signaling [1,
2]. Its regulation, particularly with respect to length, has been defined primarily by genetic …

In humans, seven evolutionarily conserved genes that cause the cilia-related disorder
Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The …

The microtubule motor kinesin-1 plays central roles in intracellular transport. It has been
widely assumed that many cellular cargos are moved by multiple kinesins and that cargos …