Characterization of drugs as antioxidant prophylactics

OI Aruoma - Free Radical Biology and Medicine, 1996 - Elsevier
There is growing interest in the evaluation of drugs (prescription only medicines and over-
the-counter medicines) as antioxidant prophylactics. Although free radical mechanism in …

1, 4‐Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

A Velena, N Zarkovic, K Gall Troselj… - Oxidative medicine …, 2016 - Wiley Online Library
Many 1, 4‐dihydropyridines (DHPs) possess redox properties. In this review DHPs are
surveyed as protectors against oxidative stress (OS) and related disorders, considering the …

Mechanisms of hydrogen peroxide-induced contraction of rat aorta

Z Yang, T Zheng, A Zhang, BT Altura… - European journal of …, 1998 - Elsevier
It has been suggested that reactive oxygen species may be involved in the regulation of
vascular tone. However, the underlying mechanisms remain to be elucidated. The present …

Biological fate and effects of propranolol in an experimental aquatic food chain

J Ding, G Lu, S Li, Y Nie, J Liu - Science of the Total Environment, 2015 - Elsevier
The aim of this study was to evaluate the trophic transfer of the β-blocker propranolol (PRP)
in an experimental aquatic food chain involving the green algae Scenedesmus obliquus, the …

Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation

H Sugawara, K Tobise, K Kikuchi - Hypertension Research, 1996 - jstage.jst.go.jp
We studied the antioxidant effects of nine calcium antagonists (nisoldipine, benidipine,
nilvadipine, felodipine, nicardipine; nitrendipine, nifedipine, verapamil, and diltiazem) by …

Cardioprotective Effect of Propranolol From Alcohol‐Induced Heart Muscle Damage as Assessed by Plasma Cardiac Troponin‐T

VB Patel, R Ajmal, RA Sherwood… - Alcoholism: Clinical …, 2001 - Wiley Online Library
Background: Heavy alcohol consumption from either long‐term misuse or binge drinking is
associated with poor cardiac contractility, mitochondrial dysfunction, and ventricular …

Antioxidant effects of photodegradation product of nifedipine

Y Horinouchi, K Tsuchiya, C Taoka… - Chemical and …, 2011 - jstage.jst.go.jp
Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a
protective agent for endothelial cells, and that the activity is unrelated to its calcium channel …

Structural effects on the reactivity 1, 4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation

C Yanez, C Lopez-Alarcon, C Camargo… - Bioorganic & medicinal …, 2004 - Elsevier
A series of eight commercial C-4 substituted 1, 4-dihydropyridines and other synthesized
related compounds were tested for direct potential scavenger effect towards alkylperoxyl …

Modulation by dihydropyridine‐type calcium channel antagonists of cytokine‐inducible gene expression in vascular smooth muscle cells

M Cattaruzza, R Wachter, AH Wagner… - British journal of …, 2000 - Wiley Online Library
The 1, 4‐dihydropyridine nifedipine is frequently used in the therapy of hypertension and
heart failure. In addition, nifedipine has been shown to exert distinct anti‐arteriosclerotic …

Reactivity of 1, 4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation

C López-Alarcón, P Navarrete… - Chemical research in …, 2003 - ACS Publications
A series of C4-substituted 1, 4-dihydropyridines (DHP) with either secondary or tertiary
nitrogen in the dihydropyridine ring were synthesized. All of these compounds together with …